منابع مشابه
Necrotic Hepatic Hemangioma Mimicking Liver Metastasis at
73-year-old male was a victim of sigmoid colon cancer. He received a sigmoid-colectomy 10 years ago. He suffered from watery diarrhea about 3 times per day for 2-3 months recently. Magnetic resonance imaging (MRI) showed a heterogeneously enhanced mass in the transverse colon and a 9x8.2 cm well-marginated mass in the left lobe of the liver. The hepatic tumor showed mixed signal intensity on T1...
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The metastatic organotropism has been one of the cancer's greatest mysteries since the 'seed and soil' hypothesis. Although the role of EGFR in cancer cells is well studied, the effects of secreted EGFR transported by exosomes are less understood. Here we show that EGFR in exosomes secreted from gastric cancer cells can be delivered into the liver and is integrated on the plasma membrane of liv...
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Cancer metastasis is facilitated by cell-cell interactions between cancer cells and endothelial cells in distant tissues. In addition, cancer cell interactions with platelets and leukocytes contribute to cancer cell adhesion, extravasation, and the establishment of metastatic lesions. Selectins are carbohydrate-binding molecules that bind to sialylated, fucosylated glycan structures, and are fo...
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Hepatic metastasis is responsible for the majority of colorectal cancer (CRC)-related mortalities. Although Gankyrin (PSMD10) has been implicated in cancer metastasis, its exact role and underlying mechanisms of CRC hepatic metastasis remain largely unknown. Herein, we showed that the expression of Gankyrin was higher in primary CRC with hepatic metastasis compared with CRC without metastasis. ...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2020
ISSN: 2379-3708
DOI: 10.1172/jci.insight.136215